Definitely could happen again, and will eventually happen again. All civilizations fall eventually. Current food production, transportation, and preservation is almost entirely ran on fossil fuels (fertilizer, pesticides, machinery, refrigeration, etc). Climate change will eventually make a significant proportion of current productive land unproductive. Climate change, topsoil loss, super-bugs, super-weeds, etc are also already causing problems; and many experts think the current way of doing agriculture are unsustainable.